NEWS & EVENTS
A smiling woman has her blood pressure checked by a medical professional.

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension

October 27 - 29, 2021
Virtual Zoom Webinar - 12:00 ‒ 4:00 p.m. EDT

Description

The NHLBI hosted an event to review the state of the science and evidence for links between circadian rhythms in blood pressure regulation and chronotherapy for hypertension. This workshop, which was sponsored by the Division of Cardiovascular Sciences (DCVS) in coordination with the National Center on Sleep Disorders Research, also identified research gaps and opportunities that are inhibiting progress in understanding these important connections. The virtual event was free and open to the public.

Featured session topics included:

  • Phenotypic Manifestations of Circadian Rhythm of Blood Pressure
  • Abnormal Circadian Rhythm: Blood Pressure, Target Organ Damage, and Disease
  • Mechanisms Influencing Circadian Rhythm of Blood Pressure
  • Additional Factors Associated with Circadian Rhythm of Blood Pressure
  • Interventions

Agenda

12:00-12:25 p.m.
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Welcoming Remarks and Meeting Overview

Introduction – Dr.Young Oh, Meeting Organizer, DCVS, NHLBI

Welcome – Dr.David Goff, Director, DCVS, NHLBI

Goals and Sessions Overview – Meeting Co-Chairs: Dr. Michelle Gumz (University of Florida) and Dr. Daichi Shimbo (Columbia University)

12:25-2:15 p.m.
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SESSION 1: Phenotypic Manifestations of Circadian Rhythm of Blood Pressure

Moderator: Dr. David Pollock (University of Alabama at Birmingham)

12:25 – 12:40 p.m.  Molecular Architecture of the Mammalian Circadian Clock Dr. Joseph Takahashi (University of Texas Southwestern)

12:40 – 12:55 p.m.  Human: Behavioral and Endogenous Circadian Factors Interact to Produce a Day/Night Pattern of Blood Pressure Dr. Steven A. Shea (Oregon Health & Science University)

12:55 – 1:10 p.m.  Human: Measurement Approaches to Circadian Rhythm of Blood Pressure Dr. George Stergiou (University of Athens, Greece)

1:10 – 1:25 p.m.  Animal: Circadian Rhythm of Blood Pressure in Rodent Models Dr. Michelle Gumz (University of Florida)

1:25 – 1:40 p.m.  Animal: Data Analysis for Circadian Rhythm of Blood Pressure Dr. Jessica R. Ivy (University of Edinburgh, UK)

1:40 – 2:00 p.m.  Panel Discussion with All Session Speakers – Moderator: Dr. David Pollock (University of Alabama at Birmingham)

2:00 – 2:15 p.m.  Break

2:15 - 4:05 p.m.
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SESSION 2: Abnormal Circadian Rhythm: Blood Pressure, Target Organ Damage, and Disease

Moderator: Dr. Bina Joe (University of Toledo)

2:15 – 2:30 p.m.  Human: Cardiovascular Dr. Paul Muntner (University of Alabama at Birmingham)

2:30 – 2:45 p.m.  Human: Kidney Dr. Mahboob Rahman (Case Western Reserve University)

2:45 – 3:00 p.m.  Human: Brain, Cognition, and Dementia Dr. Christian Benedict (University of Uppsala, Sweden)

3:00 – 3:15 p.m.  Human: Night Shift Dr. Eva Schernhammer (Harvard)

3:15 – 3:30 p.m.  Animal: Shift Work, Sex Differences, and Stroke Dr. David J. Earnest (Texas A&M University)

3:30 – 3:45 p.m.  Animal: Vasculature Dr. Yabing Chen (University of Alabama at Birmingham)

3:45 – 4:05 p.m.  Panel Discussion with All Session Speakers Moderator: Dr. Bina Joe (University of Toledo)

4:05 p.m.  Adjourn

12:00 - 12:10 p.m.
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Welcome and Sessions Overview

Co-Chairs: Dr. Michelle Gumz (University of Florida) and Dr. Daichi Shimbo (Columbia University)

12:10 - 2:15 p.m.
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SESSION 3: Mechanisms Influencing Circadian Rhythm of Blood Pressure

Moderator: Dr. David Stepp (Augusta University)

12:10 - 12:25 p.m.  Circadian Clock Gene Networks in Animals and Human Dr. John B. Hogenesch (University of Cincinnati)

12:25 – 12:40 p.m.  Human: GWAS, Genes, and Genetics Dr. Xiaoling Wang (Augusta University)

12:40 – 12:55 p.m.  Human: Epigenetics Dr. Mingyu Liang (Medical College of Wisconsin)

12:55 – 1:10 p.m.  Human: Sleep Disturbances and Disorders Dr. Marwah Abdalla (Columbia University)

1:10 – 1:25 p.m.  Animal: Food Intake Timing in Diabetic Animal Model Dr. Ming Gong (University of Kentucky)

1:25 – 1:40 p.m.  Animal: Food Intake Timing in Animal Model Dr. David Pollock (University of Alabama at Birmingham)

1:40 – 2:00 p.m.  Panel Discussion with All Session Speakers Moderator: Dr. David Stepp (Augusta University)

2:00 – 2:15 p.m.  Break

2:15 - 4:05 p.m.
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SESSION 4: Additional Factors Associated with Circadian Rhythm of Blood Pressure

Moderator: Dr. Susan Redline (Harvard University)

2:15 - 2:30 p.m.  Human: Aging, Sex, and SleepDr. Phyllis C. Zee (Northwestern University)

2:30 – 2:45 p.m.  Human: Health Disparities Dr. Mercedes Carnethon (Northwestern University)

2:45 – 3:00 p.m.  Animal: Obesity Dr. David Stepp (Augusta University)

3:00 – 3:15 p.m.  Animal: Salt – Dr. Jennifer Pollock (University of Alabama at Birmingham)

3:15 – 3:30 p.m.  Animal: Aging Dr. Dan Rudic (Augusta University)

3:30 – 3:45 p.m.  Animal: Microbiome Dr. Bina Joe (University of Toledo)

3:45 – 4:05 p.m.  Panel Discussion with All Session Speakers Moderator: Dr. Susan Redline (Harvard University)

4:05 p.m.  Adjourn

12:00 - 12:10 p.m.
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Welcome and Sessions Overview

Co-Chairs: Michelle Gumz (University of Florida) and Dr. Daichi Shimbo (Columbia University)

12:10 - 2:20 p.m.
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SESSION 5: Interventions

Moderator: Dr. Tami Martino (University of Guelph, Canada)

12:10 – 12:20 p.m.  Introduction: Chronotherapy for Hypertension Dr. Daichi Shimbo (Columbia University)

12:20 – 12:35 p.m.  Human: Non-Pharmacologic (Sleep Duration & Timing)Dr. Marie-Pierre St-Onge (Columbia University)

12:35 – 12:50 p.m.  Animal: Non-Pharmacologic (Time Restricted Feeding) Dr. Karen Gamble (University of Alabama at Birmingham)

12:50 – 1:05 p.m.  Pharmacologic (HYGIA Trial) Dr. Eric J. MacLaughlin (Texas Tech University)

1:05 – 1:20 p.m.  Pharmacologic (TIME Trial) Dr. Amy Rogers (University of Dundee, UK)

1:20 – 1:35 p.m.  Pharmacologic (BedMed and BedMed-Frail Trials) Dr. Scott R. Garrison (University of Alberta, Canada)

1:35 – 1:50 p.m.  Gaps and Future Directions on Chronotherapy Interventions: Translation from Animals to Humans Dr. Tami Martino (University of Guelph, Canada)

1:50 – 2:10 p.m.  Panel Discussion with All Session Speakers Moderator: Dr. Tami Martino (University of Guelph, Canada)

2:10 – 2:20 p.m.  Break

2:20 - 4:00 p.m.
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SESSION 6: Breakout Sessions

SESSION 6: Breakout Sessions

Breakout Room Moderators

(i) Basic/Translational Science: Dr. David Pollock (University of Alabama at Birmingham), Dr. Bina Joe (University of Toledo), and Dr. David Stepp (Augusta University)

(ii) Population/Clinical Science: Dr. Susan Redline (Harvard University) and Dr.Tami Martino (University of Guelph, Canada)

Main Room Moderators – Dr. Michelle Gumz (University of Florida) and Dr. Daichi Shimbo (Columbia University)

2:20 – 3:00 p.m.  Breakout Sessions (For Invited Speakers Only; Break for Other Participants)
Two break out rooms (Invited Speakers Only – a separate zoom link will be provided):
(i) basic/translational science and (ii) population/clinical science.
Each room will identify (1) high priority research questions, (2) barriers to addressing these gaps and questions, and (3) recommendations on removing barriers.

3:00 – 4:00 p.m.  Breakout Session Summary and Discussion
Return to main room. Spokespersons for basic/translational science room and population/clinical science room will each report on the summary of the discussion. Moderated discussion will occur after presentations.

4:00 p.m.  Closing Including Next Steps Dr. Young Oh (DCVS, NHLBI)