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Identifying Research Directions in Sleep, Circadian Biology, and COVID-19

Webinar

Description

This workshop will explore the state of the science on COVID-19-related sleep and circadian biology research. The presenters will discuss critical findings and identify scientific questions for basic research, clinical investigations, and societal impact studies about sleep and the COVID-19 pandemic. They will also examine how the pandemic has affected sleep across populations, including its relationship to health disparities and sex and gender influences. The goal of this workshop is to identify knowledge gaps and research opportunities that should be prioritized in the interest of medicine, public health, and safety.

Agenda Highlights

  • Sleep and Circadian Rhythms: Vulnerability and Resilience to SARS-CoV-2
  • Psychosocial Factors and Sleep during the Pandemic
  • Sleep and Circadian Biology in the Context of PASC, including Long COVID
  • Novel and Innovative Approaches to Understand Sleep and Circadian Effects of COVID-19

Co-Chairs

Reena Mehra, M.D. and Elizabeth Klerman, M.D., Ph.D.

Collaborting Institutes and Centers

National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute on Minority Health and Health Disparities (NIMHD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Cancer Institute (NCI)
Office of Behavioral and Social Sciences Research (OBSSR)

Agenda

9:15 AM
-
Opening and Overview
(00:01 in Videocast)

Workshop Overview
Marishka K. Brown, Ph.D, Director of the National Center on Sleep Disorders Research Marishka K. Brown, Ph.D, Director of the National Center on Sleep Disorders Research

Plenary
Importance of Sleep and Circadian Rhythms in Human Physiology and Pathophysiology
Elizabeth Klerman, M.D., Ph.D., Massachusetts General Hospital

Sleep and Circadian Disruption: Prevalent and Missed Opportunity Targets in COVID-19 and PASC?
Reena Mehra, M.D., M.S., Cleveland Clinic

Honorary Keynote (25:30)
Brain Cytokine Complexity Local Sleep: Lessons from Influenza
James M. Krueger, Ph.D. Washington State University

9:45 AM
-
Session I: Sleep and Circadian Rhythms: Vulnerability and Resilience to SARS-CoV-2
(38:26 in Videocast)

Circadian Clocks, Sleep, and Recovery
Jeffery Haspel, M.D., Ph.D., Washington University St. Louis

Diurnal variation in SARS-CoV-2 PCR test results: Test positivity varies by time of day
Candace D. McNaughton, M.D. Ph.D. MPH, and Carl Johnson, Ph.D., Vanderbilt University

The Impact of SARS-CoV-2 Infection on Ventilatory Control
Russell Ray, Ph.D., Baylor College of Medicine

Circadian Rhythms, Seasonality, and Infectious Disease
Micaela E. Martinez, Ph.D., Emory University

Sleep and the Immune Response
Monika Haack, Ph.D., Harvard Medical School

Sleep Health and Resilience – in the context of acute SARS-CoV2 infection and severity
Kelly Baron, Ph.D., University of Utah

Session I Panel Discussion – Moderator: Aaron Laposky, Ph.D., NCSDR (2:14:45)

11:30 AM
-
30- minute Lunch Break

12:00 PM
-
Session II: Psychosocial Factors and Sleep During the Pandemic
(2:31:40 in Videocast)

Influence of Socio-cultural Factors on Sleep Disruption and COVID-19
Dayna Johnson, Ph.D., Emory University

Intersection of Sleep Difficulties and Mental Health During the Pandemic
Michael Grandner, Ph.D. MTR, CBSM, FAASM, University of Arizona

The Impact of Sleep in COVID-19 on Alcohol Consumption and Mental Health in Young Adults
Ian Colrain, Ph.D., SRI International

Insomnia During the Pandemic
Rachel Manber, Ph.D., Stanford University

COVID-19 and the Vulnerability of Shift Workers
Sara B. Seidelmann, M.D., Ph.D., Columbia University

Sleep and COVID-19 in Pediatrics
Monica Roosa Ordway, Ph.D., Yale School of Nursing

Session II Panel Discussion – Moderators: Glenna S. Brewster Glasgow, Ph.D., RN, FNP-BC, Emory University AND Julio Fernandez-Mendoza, Ph.D., DBSM, Penn State (4:14:45)

1:45 PM
-
10-minute Break

1:55 PM
-
Sleep III: Sleep and Circadian Biology in the Context of PASC, including Long COVID
(4:28:00 in Videocast)

Sleep Disorders and Circadian Disruption as Symptoms and Modifiers of PASC
Janet Mullington, Ph.D., Harvard Medical School

Exploring the Neurological Aspects of COVID-19 and PASC
Allison Navis, M.D., Icahn School of Medicine, Mt. Sinai

Post-COVID-19 Fatigue
Laura Lewis, Ph.D., Boston University

PASC and post-COVID-19 Ventilatory Control
Safwan Badr, M.D., Wayne State University

Session III Panel Discussion – Josh Fessel, MD, Ph.D., Division of Lung Diseases/NHLBI (5:28:45)

3:10 PM
-
5-minute Stretch Break

3:15 PM
-
Session IV: Novel and Innovative Approaches to Understand Sleep and Circadian Effects of COVID-19
(5:36:33 in Videocast)

Breathing and COVID-19 outcomes
Scott Sands, Ph.D., Brigham and Women's Hospital and Harvard Medical School

Wearables and the Tracking of Sleep and Circadian Phase
Daniel Forger, Ph.D., University of Michigan

EHR Data to Understand Sleep and COVID-19 Morbidity and Mortality
Brian Cade, Ph.D., Brigham and Women's Hospital

Sleep Deficiency & Disparity during the Pandemic: What Can We Do About It?
Wendy Troxel, Ph.D. , RAND Corporation

Session IV Panel Discussion – Moderator: Azizi Seixas, Ph.D., NYU Langone Health (6:39:15)

4:30 PM
-
Workshop Summary and Closing Remarks
(6:53:50 in Videocast)

5:00 PM
-
Adjourn